ODCs

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6 OMIM references -
5 associated genes
9 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
14 signs/symptoms

Split hand-split foot malformation

Bladder exstrophy


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	BTRC	(0.79)	TP63

Citations in the biomedical literature:

Split hand-split foot malformation		Bladder exstrophy
	Synonym(s): - Ectrodactyly - Lobster-claw deformity - SHFM - Split hand foot malformation		Synonym(s): - Classic exstrophy of the bladder

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare abdominal surgical disease - Rare developmental defect during embryogenesis - Rare genetic disease - Rare renal disease - Rare urogenital disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: multigenic/multifactorial

	External references: 6 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: D001746

Split hand-split foot malformation		Bladder exstrophy
	Very frequent - Autosomal dominant inheritance - Oligodactyly / ectrodactyly of fingers Frequent - Syndactyly of fingers / interdigital palm Occasional - Aniridia / iris hypoplasia - Autosomal recessive inheritance - Hand agenesis / absence - Sensorineural deafness / hearing loss - Trident hand / split hand / abnormal median ray - X-linked recessive inheritance		Very frequent - Anus / rectum anomalies - Bladder / cloacal exstrophy - Clitoris / labia majora / labia minora / female external genitalia hypoplasia - Hypospadias / epispadias / bent penis - Micropenis / small penis / agenesis - Umbilical hernia - Vesicorenal / vesicoureteral reflux Frequent - Inguinal / inguinoscrotal / crural hernia - Recurrent urinary infections - Urethral anomalies / stenosis / posterior urethral valves / megalocystis Occasional - Encopresis / fecal incontinence - Intestinal / gut / bowel malrotation - Omphalocele / exomphalos - Short bowel